Associate Professor Dr. Arinthip Thamchaipenet

  • Position: Associate Professor
  • Office number:
  • Lab number:
  • E-mail:
  • Contacts: 662-562-5444, 5555 ext. 4208 (off), 4202 (lab)
  • Education:
  • 1987B.Sc. (Microbiology)Chulalongkorn University, Bangkok
    1990 M.Sc. (Industrial Microbiology)Chulalongkorn University, Bangkok
    1994Ph.D. (Molecular Genetics)University of Glasgow, Glasgow, UK
    1998 Post-Doctoral Fellow (Combinatorial Biosynthesis)Kosan Biosciences, Inc., California, USA

    Research interestsGrantsAdditional informationPublication
  • Biology and Molecular Genetics of Streptomyces and related genera
  • Genetics and Biosynthetic Pathway of Polyketide Antibiotics
  • Combinatorial Biosynthesis
  • Endophytic actinomycetes: plant growth regulating agents and bioactive compounds


    2006-2009JST program "Asia Science and Technology Cooperation
    Promotion Strategy: Solution of Research Issues Shared by Asian Regions",
    Osaka University, Japan. Topic: Selection and identification of endophytic
    actinomycetes towards novel bioactive compounds discovery
    2006-2009TRF-CHE Research Grant for Mid-Career University Faculty.
    Topic: Isolation and identification of endophytic/rhizosperic actinomycetes that
    produce bioactive compounds against plant pathogenic microorganisms.
    2007-2009BIOTEC, NSTDA. Title: Construction of mutants by
    manipulation of genes involved in shikimate pathway in Streptomyces)
    2008-2010 Prime Minister’s Initiative for International Education 2
    (PMI2) Connect-Research Co-operation Award, British Council, UK. Title:
    Expression of novel actinobacteria TypeIII polyketide synthase (PKS) gene:
    towards new natural product discovery.
      Courses: 416311 Principle of Genetics
      416312 Laboratory of Genetics
      416454 Introduction to Bioinformatics
      416458 Laboratory in Genetic Engineering
      416551 Intensive Genetics
      416553 Molecular Genetics
      416653 Advanced Molecular Genetics
      416691 Research Techniques in Geentics


      Duangmal, K., Mingma, R., Thamchaipenet, A., Matsumoto, A. and
      Takahashi, Y. (2010). Saccharopolyspora phatthalungensis sp. nov.,
      isolated from rhizospheric soil of Hevea brasiliensis. Int. J. Syst. Evol.
      Microbiol. (in press). doi:10.1099/ijs.0.018275-0
      Indananda, C., Matsumoto, A., Inahashi, Y., Takahashi, Y., Duangmal, K.
      and Thamchaipenet, A. (2010). Actinophytocola gen. nov., a new genus
      of the family Pseudonocardiaceae and description of a new species,
      Actinophytocola oryzae sp. nov., isolated from root of Thai glutinous rice
      plant. Int. J. Syst. Evol. Microbiol. (in press). doi: 10.1099/ijs.0.008417-0
      Thamchaipenet, A., Indananda, C., Bunyoo, C., Duangmal, K.,
      Matsumoto, A. and Takahashi, Y. (2010). Actinoallomurus acaciae sp.
      nov., a novel endophytic actinomycete isolated from Acacia auriculiformis
      A. Cunn. ex Benth. in Thailand. Int. J. Syst. Evol. Microbiol. (in press).
      doi: 10.1099/ijs.0.012237-0
      Thamchaipenet, A. (2009). Endophytic actinomycetes from Thai tropical
      plants. In: Proposal on Efficient Utilization of Thai Bioresources (supplementary volume). Nihira, T. (ed.). International Center for
      Biotechnology, Osaka University, Japan. pp. 1-4.
      Kokaew, K., Srisuk, N., Limtong, S. and Thamchaipenet, A. (2009).
      Cloning and nucleotide sequence analysis of xylose reductase (XR) gene
      from thermotolerant methylotrophic yeast Ogataea siamensis N22. Thai J.
      Genet. 2: 66-71.
      Duangmal, K., Thamchaipenet, A., Matsumoto, A. and Takahashi, Y.
      (2009). Pseudonocardia acaciae sp. nov., isolated from Acacia
      auriculiformis A. Cunn. ex Benth. Int. J. Syst. Evol. Microbiol. 59: 1487-
      Phithakrotchanakoon, C., Daduang, R., Thamchaipenet, A., Wangkam,
      T., Srikhirin, T., Eurwilaichitr, L. and Champreda, V. (2009). Heterologous
      expression of polyhydroxyalkanoate depolymerase from Thermobifida sp.
      in Pichia pastoris and catalytic analysis by surface plasmon resonance.
      Appl. Microbiol. Biotechnol. 82: 131-140.
      Anusonpornpurm, S., Lersrutaiyotin, R., Rattanakreetakul, C.,
      Thamchaipenet, A. and Weerathaworn, P. (2008). Identifying QTLs for
      fiber content and agronomic characters in sugarcane using AFLP markers.
      Kasetsart J. (Nat. Sci.) 42(4): 668-675.
      Pinyoowong, D., Jittapalapong, S., Peyachoknagul, S. and
      Thamchaipenet, A. (2008). Topology prediction and motifs identification of
      bicyclomycin resistance protein of Ehrlichia canis strain Bangkok.
      Biomed. & Pharmacol. J. 1: 1-8.
      Duangmal, K., Thamchaipenet, A., Ara, I., Matsumoto, A. and Takahashi,
      Y. (2008). Kineococcus gynurae sp. nov., isolated from Thai medicinal
      plant. Int. J. Syst. Evol. Microbiol. 58: 2439-2442.
      Pinyoowong, D., Jittapalapong, S., Suksawat, F., Stich, R.W. and
      Thamchaipenet, A. (2008). Molecular characterization of Thai Ehrlichia
      canis and Anaplasma platys strains detected in dogs. Infect. Genet. Evol.
      8: 433-438.
      Chungool, W., Thongkam, W., Ravisri, P., Thamchaipinet, A. and
      Pinphanichakarn, P. (2008). Production, purification and characterization
      of acetyl esterase from Streptomyces sp. PC22 and Its action in
      cooperation with xylanolytic enzymes on xylan degradation. World J.
      Microbiol. Biotechnol. 24: 549-556.
      Phornphisutthimas, S., Thamchaipenet, A. and Panijpan, B. (2007).
      Conjugation in Escherichia coli: a laboratory exercise. Biochem. Mol.
      Biol. Edu. 35: 440-445.
      Smphor, L., Thaveechai, N., Chowpongpang, S., Thamchaipenet, A. and
      Paradornuwat, A. (2007). Diagnosis of greening and Tristeza diseases on
      lime in Thailand by transmission electron microscope. J. Microscopy
      Society of Thailand. 21: 366-367.
      Petković, H., Cullum, J., Hranueli, D., Hunter, I.S., Perić-Concha, N.,
      Pigac, J., Thamchaipenet, A., Vujaklija, D. and Long, P.F. (2006).
      Genetics of Streptomyces rimosus, the oxytetracycline producer.
      Microbiol. Mol. Biol. Rev. 70: 704-728.
      Meinkerd, S. and Thamchaipenet, A. (2006). Two types of ketoreductase
      domains in Type I polyketide synthase system and model design for
      functional analysis. KU Sci. J. 23: 54-61 (in Thai).
      Attanoraks, S., Thamchaipenet, A., Piamsa-Nga, P. and Soonthornphisaj,
      N. (2006). Consensus selection algorithm for automatic primer design
      system. KMITL Sci. J. 6: 232-240.
      Sukhapesna, J., Amavisit, P., Wajjwalku, W., Thamchaipenet, A. and
      Sukpuaram, T. (2005). Antimicrobial resistance of Campylobacter jejuni
      isolated from chicken in Nakhon Phathom Province, Thailand. Kasetsart
      J. (Nat. Sci.) 39: 240-246.
      Nabhadalung, N., Suwanarit, A., Dell, B., Nopamornbodi, O.,
      Thamchaipenet, A. and Rungchuang, J. (2005). Effects of long-term NPfertilization
      on abundance and diversity of arbuscular mycorrhizal fungi
      under a maize cropping system. Plant Soil. 270: 371-382.
      Pinphanichakarn, P., Tangsakul, T., Thongnumwon, T., Talawanich, Y.
      and Thamchaipenet, A. (2004). Purification and characterization of β-
      xylosidase from Streptomyces sp. CH7 and its gene sequence analysis.
      World J. Microbiol. Biotechnol. 20: 727-733.
      Thamchaipenet, A. (2003). Bioinformatics. J. Sci. Soc. Thailand. 57: 125-
      127 (in Thai).
      Thamchaipenet, A., Chaipackdee, V., Kawasaki, H. and Seki, T. (2001).
      Partial 16S rDNA analysis of anti-fungal producing streptomycetes
      isolated from coastal areas of Thailand. In “Biotechnology for Sustainable
      Utilization of Biological Resources in the Tropics”. Vol. 15. Murooka, Y. et.
      al. (eds.). ICBiotech, Osaka Univ., Japan. pp. 132-137.
      Thamchaipenet, A. (1999). Multiple domain substitutions of erythromycin
      polyketide synthase to produce a combinatorial library.
      Actinomycetologica. 13: 113-119.
      Petkovic, H., Thamchaipenet, A., Zhou, L-H., Hranueli, D., Raspor, P.,
      Waterman, P. and Hunter, I.S. (1999). Disruption of the aromatase/cyclase
      from the oxytetracycline gene cluster of Streptomyces rimosus results in
      production of novel polyketides with shorter chain lengths. J. Biol. Chem.
      274: 32829-32834.
      McDowall, K.J., Thamchaipenet, A. and Hunter, I.S. (1999). Phosphate
      control of oxytetracycline production by Streptomyces rimosus is at the
      level of transcription from promoters overlapped by tandem repeats similar
      to those of the DNA-binding sites of the OmpR family. J. Bacteriol. 181:
      McDaniel, R.M., Thamchaipenet, A., Gustafsson, C., Fu, H., Betlach, M.,
      Betlach, M. and Ashley, G. (1999). Multiple genetic modifications of the
      erythromycin gene cluster to produce a library of novel "unnatural" natural
      products Proc. Natl. Acad. Sci. USA. 96: 1846-1851.
      Thamchaipenet, A. (1998). Combinatorial Biosynthesis. KU Sci. J. 16: 45-
      54 (in Thai).
      Lui, L., Thamchaipenet, A., Fu, H., Betlach, M. and Ashley, G. (1997)
      Biosynthesis of 2-nor-6-deoxyerythronolide B by rationally designed
      domain substitution. J. Am. Chem. Soc. 119: 10553-10554.
      Pinphanichakarn, P., Thamchaipenet, A. and Hunter, I.S. (1995). Cloning
      of xylanase gene from Streptomyces griseoruber 42-9 into glucose
      isomerase-producing Streptomyces cyaneus 190-1. J. Natl. Res. Council
      Thailand. 27: 1-17.
      Linton, K.J., Thamchaipenet, A. and Hunter, I.S. (1995). The impact of
      molecular genetics on understanding antibiotic biosynthesis: design of
      new drugs. Food Tech. Biotech. Rev. 32: 61-66.
      Thamchaipenet, A. and Hunter, I.S. (1995). Disruption of two genes
      encoding the putative ketoreductase and cyclase/dehydratase of
      Streptomyces rimosus involved in oxytetracycline biosynthesis. In:
      “Biotechnology Research and Applications for Sustainable Development
      (BRASD)”. Mongkolsuk, et al., (eds.). Thailand. pp. 155-160.

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